circRNA basic information
circBase ID: hsa_circ_0085533
Name: hsa_circ_MYC
Synonym: circMyc
Host Gene: -
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal mammary epidermal cells (MCF-10A), six breast cancer cells (MCF-7, T47D, SK-BR-3, BT-20, MDA-MB-231, MDA-MB-468)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HuR, SREBP1
Associated microRNA: -
Biological function: Genetic knockdown of circMyc mediated by lentiviral vector significantly inhibited TNBC cell proliferation and invasion
Molecular mechanism: circMyc/HuR/SREBP1 axis
Survival: -
Supported No.:
 1
Description:

Collectively, our findings characterize a novel Myc-derived circRNA controlling TNBC tumorigenesis via regulation of metabolic reprogramming, implying a promising therapeutic target.
Other information
Title:

Myc derived circRNA promotes triple-negative breast cancer progression via reprogramming fatty acid metabolism.

Journal: Discov Oncol
Published: 2023/5/13
PubMed ID: 37173608