circRNA basic information
circBase ID: hsa_circ_0003747
Name: hsa_circ_ALS2CR8
Synonym: circ_0003747
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal thyroid cells (Nthy-ori3_1), TC derived cell lines (TPC-1, IHH4, B-CPAP, CAL-62)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PLCD3
Associated microRNA: hsa-miR-338-3p
Biological function: Circ_0003747 knockdown reduced TC cell viability, proliferation, migration, and invasion while increasing cell apoptosis. the knockdown of circ_0003747 remarkably suppressed tumour size and growth
Molecular mechanism: circ_0003747/hsa-miR-338-3p/PLCD3 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In conclusion, circ_0003747 facilitated the biological progression of TC by modulating the miR-338-3p/PLCD3 axis, and it may be a new target for TC treatment.
Other information
Title:

Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression.

Journal: Epigenetics
Published: 2023/5/11
PubMed ID: 37166441