circRNA basic information
circBase ID: hsa_circ_0071803
Name: hsa_circ_SEMA5A
Synonym: circSEMA5A
Host Gene: hsa-miR-195-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Colorectal cell lines (LoVo, SW620, SW480, Caco-2), normal colonic epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: CCNE1
Associated microRNA: hsa-miR-195-5p
Biological function: CircSEMA5A promoted CRC proliferative, migratory, and invasive capabilities in cultured cells and facilitated the tumorigenic process in xenografts; however, circSEMA5A silencing repressed tumor metastasis in CRC cells
Molecular mechanism: circSEMA5A/hsa-miR-195-5p/CCNE1 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

CircSEMA5A facilitates CRC cell malignancy and tumor growth through sponging miR-195-5p to upregulate CCNE1, thus providing a new direction for CRC diagnosis and targeted therapy.
Other information
Title:

Circular RNA circSEMA5A facilitates colorectal cancer development by regulating microRNA-195-5p to target CCNE1 axis.

Journal: Cell Signal
Published: 2023/5/11
PubMed ID: 37164546