circRNA basic information
circBase ID: hsa_circ_0060467
Name: hsa_circ_MYBL2
Synonym: circ_0060467
Host Gene: hsa-miR-1205
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MCF-7, BT-474, MDA-MB-468, HCC38, MDA-MB-231, BT-549, SKBR-3, MCF-10A, Hs 578Bst cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F1, eIF4A3
Associated microRNA: hsa-miR-1205
Biological function: circMYBL2 can facilitate the proliferation and liver metastasis of BC
Molecular mechanism: circMYBL2/hsa-miR-1205/E2F1 and circMYBL2/eIF4A3/E2F1 axes, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our findings showed that circMYBL2 promoted the tumorigenesis and aggressiveness of BC through the circMYBL2/miR-1205/E2F1 and circMYBL2/eIF4A3/E2F1 axes, which may provide a novel targeted therapy for patients with BCLM.
Other information
Title:

Hsa_circ_0060467 promotes breast cancer liver metastasis by complexing with eIF4A3 and sponging miR-1205.

Journal: Cell Death Discov
Published: 2023/5/10
PubMed ID: 37160894