circRNA basic information
circBase ID: hsa_circ_0002696
Name: hsa_circ_METTL9
Synonym: circ-METTL9
Host Gene: hsa-miR-551b-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human colon cancer cell lines (Caco2, HCT116, SW480, SW620, RKO, LoVo, DLD-1, HT-29)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK6
Associated microRNA: hsa-miR-551b-5p
Biological function: circ-METTL9 overexpression promoted CRC cells proliferation and migration in vitro, and simultaneously enhanced CRC tumor growth and metastasis in vivo
Molecular mechanism: circ-METTL9/hsa-miR-551b-5p/CDK6 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, our findings highlight a novel oncogenic function of circ-METTL9 in CRC progression via circ-METTL9/miR-551b-5p/CDK6 axis, which may serve as a prognostic biomarker and therapeutic target for CRC patients.
Other information
Title:

METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6.

Journal: Carcinogenesis
Published: 2023/5/9
PubMed ID: 37158456