circRNA basic information
circBase ID: hsa_circ_0085535
Name: hsa_circ_MYC
Synonym: circREOS
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human hFOB 1.19, OS cell lines (143B, HOS, SJSA-1, MG-63)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: CircREOS suppresses MYC expression, lipid metabolism and growth, invasion in OS cells
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

Taken together, these results indicate that circREOS suppress lipid synthesis and OS progression through inhibiting HuR-mediated MYC activation, providing a potential therapeutic target for OS.
Other information
Title:

CircREOS suppresses lipid synthesis and osteosarcoma progression through inhibiting HuR-mediated MYC activation.

Journal: J Cancer
Published: 2023/5/8
PubMed ID: 37151387