circRNA basic information
circBase ID: hsa_circ_0002984
Name: hsa_circ_ARHGAP32
Synonym: circ_0002984
Host Gene: hsa-miR-543
 
 
 
Disease basic information
DO ID:
 7148
DO name: rheumatoid arthritis
Disease details: rheumatoid arthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Rheumatoid arthritis fibroblast-like synoviocytes (MH7A), normal fibroblast-like synoviocytes (FLS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PCSK6
Associated microRNA: hsa-miR-543
Biological function: Circ_0002984 introduction facilitated RAFLS cell proliferation, migration and inflammatory response and repressed apoptosis, but circ_0002984 knockdown had an opposite role
Molecular mechanism: Circ_0002984/hsa-miR-543/PCSK6 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0002984 promoted RAFLS proliferation, migration and inflammatory cytokine secretion and inhibited apoptosis by binding to miR-543 to induce PCSK6 production, providing a potential target for RA therapy.
Other information
Title:

Circ_0002984 promotes proliferation, migration and inflammatory cytokine secretion and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes by inducing PCSK6 through miR-543.

Journal: J Orthop Surg Res
Published: 2023/5/7
PubMed ID: 37149637