circRNA basic information
circBase ID: hsa_circ_0066596
Name: hsa_circ_EPHA3
Synonym: circEPHA3
Host Gene: hsa-miR-513a-3p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PCa cell lines (22Rv1, LNCaP, DU145, PC-3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: BMP2
Associated microRNA: hsa-miR-513a-3p
Biological function: Transwell assays, and animal experiments revealed that circEPHA3 prohibited the progression and metastasis of PCa in vivo and in vitro
Molecular mechanism: circEPHA3/hsa-miR-513a-3p/BMP2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

As a tumor suppressor, circEPHA3 inhibited the proliferation and metastasis of PCa cells through the miR-513a-3p/BMP2 axis, suggesting that circEPHA3 might be a potential therapeutic target for PCa.
Other information
Title:

Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis.

Journal: J Transl Med
Published: 2023/4/29
PubMed ID: 37118847