circRNA basic information
circBase ID: hsa_circ_0003141
Name: hsa_circ_UBAP2
Synonym: circUBAP2
Host Gene: hsa-miR-496
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BC cell lines (RT4, T24, UMUC3, J82, SW780), uroepithelial cell line (SV-HUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TOP2A
Associated microRNA: hsa-miR-496
Biological function: knockdown of circUBAP2 could suppress BC cell growth, migration, invasion, and aerobic glycolysis in vitro, as well as impede BC growth in nude mice.
Molecular mechanism: circUBAP2/hsa-miR-496/TOP2A axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Silencing of circUBAP2 could suppress BC growth, invasion, migration, and aerobic glycolysis by the miR-496/TOP2A axis, suggesting a promising target for the molecular targeted therapies of BC.
Other information
Title:

Circular RNA Ubiquitin-associated Protein 2 Silencing Suppresses Bladder Cancer Progression by Downregulating DNA Topoisomerase 2-alpha Through Sponging miR-496.

Journal: Eur Urol Open Sci
Published: 2023/4/27
PubMed ID: 37101770