circRNA basic information
circBase ID: hsa_circ_0058058
Name: hsa_circ_ATIC
Synonym: circ_0058058
Host Gene: hsa-miR-557
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDL1
Associated microRNA: hsa-miR-557
Biological function: Knockdown of circ_0058058 repressed cell proliferation, invasion, angiogenesis, and immune escape while contributed to apoptosis in PC cells
Molecular mechanism: circ_0058058/hsa-miR-557/PDL1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our findings suggested that circ_0058058 served as miR-557 sponge to upregulate PDL1, thereby triggering PC proliferation, invasion, angiogenesis, and immune escape.
Other information
Title:

Circ_0058058 Drives the Malignant Phenotypes and Immune Evasion of Pancreatic Cancer by the MicroRNA-557-Dependent Regulation of PDL1.

Journal: Pancreas
Published: 2023/4/26
PubMed ID: 37099790