circRNA basic information
circBase ID: hsa_circ_0069249
Name: hsa_circ_DHPR
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (HCCLM3, MHCC97H, Huh7, SMMC7721, Bel-7402, Hep3B, HepG2)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: RASGEF1B
Associated microRNA: -
Biological function: CircDHPR overexpression inhibits tumor growth and metastasis in vitro and in vivo
Molecular mechanism: circDHPR/hsa-miR-3194-5p/RASGEF1B axis, miRNA sponge
Survival: better
Supported No.:
 1
Description:

We confirmed that circDHPR overexpression inhibited HCC growth and metastasis by sponging miR-3194-5p to upregulate the expression of RASGEF1B, which is regarded as a suppressor of the Ras/MAPK signaling pathway.
Other information
Title:

Aberrant expression of circular RNA DHPR facilitates tumor growth and metastasis by regulating the RASGEF1B/RAS/MAPK axis in hepatocellular carcinoma.

Journal: Cell Oncol (Dordr)
Published: 2023/4/26
PubMed ID: 37099250