circRNA basic information
circBase ID: hsa_circ_0004585
Name: hsa_circ_KIAA1199
Synonym: circ_0004585
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal colon epithelial cells (NCM460), CRC cell lines (RKO, HCT-116, SW480)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZFX
Associated microRNA: hsa-miR-338-3p
Biological function: Silencing of circ_0004585 inhibited proliferation, angiogenesis, and EMT and triggered apoptosis in CRC cells. Consistently, circ_0004585 depletion blocked tumor growth in vivo.
Molecular mechanism: circ_0004585/hsa-miR-338-3p/ZFX axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

Circ_0004585 facilitated CRC progression through modulating miR-338-3p/ZFX/MEK/ERK pathway, which might provide a potential therapeutic target for CRC.
Other information
Title:

Circ_0004585 Facilitates Tumorigenesis of Colorectal Cancer Via Modulating the miR-338-3p/ZFX Axis and Activating the MEK/ERK Pathway.

Journal: Cell Mol Bioeng
Published: 2023/4/25
PubMed ID: 37096071