circRNA basic information
circBase ID: hsa_circ_0004680
Name: hsa_circ_CCT3
Synonym: circ-CCT3
Host Gene: hsa-miR-378a-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ALKBH5, METTL3, FLT-1
Associated microRNA: hsa-miR-378a-3p
Biological function: Knocking-down of circ-CCT3 inhibited the proliferation, invasion and migration of HCC cells, and angiogenesis of HUVEC
Molecular mechanism: Circ-CCT3/hsa-miR-378a-3p/FLT1 axis, miRNA sponge, circ-CCT3/ALKBH5/METTL3 axis
Survival: poor
Supported No.:
 3
Description:

Circ-CCT3 was significantly up-regulated in HCC and promoted liver cancer development via miR-378a-3p-FLT1 axis. It was also found that circ-CCT3 was under m A-modification mediated by ALKBH5 and METTL3.
Other information
Title:

m(6)A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression.

Journal: Epigenetics
Published: 2023/4/24
PubMed ID: 37092305