circRNA basic information
circBase ID: hsa_circ_0133744
Name: hsa_circ_INSIG1
Synonym: circINSIG1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell lines (HCT8, DLD1, HCT116, SW620, CaCO2, HT29), normal human intestinal epithelial cell lines (HIEC-6), human embryonic kidney cells (293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: INSIG1, EIF4A3
Associated microRNA: -
Biological function: circINSIG1-121 promotes CRC proliferation and metastasis
Molecular mechanism: circINSIG1/INSIG1 axis
Survival: poor
Supported No.:
 1
Description:

circINSIG1 presents an epigenetic mechanism which provides insights into the crosstalk between hypoxia and cholesterol metabolism, and provides a promising therapeutic target for the treatment of CRC.
Other information
Title:

A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer.

Journal: Mol Cancer
Published: 2023/4/23
PubMed ID: 37087475