circRNA basic information
circBase ID: hsa_circ_0001772
Name: hsa_circ_RBM33
Synonym: circRBM33
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC H1975 cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: DNMT1, IL-6
Associated microRNA: -
Biological function: knockdown of circRBM33 inhibited H1975 proliferation, migration and invasion, changed cell cycle and promoted apoptosis. In vivo, knockdown of circRBM33 inhibited tumour growth
Molecular mechanism: circRBM33/DNMT1/IL-6 axis
Survival: -
Supported No.:
 1
Description:

CircRBM33 may combine with DNMT1, and regulate the resistance of H1975 osimertinib-resistant cells to osimertinib that mediated by IL6.
Other information
Title:

CircRBM33 promotes migration, invasion and mediates osimertinib resistance in non-small cell lung cancer cell line.

Journal: Ann Transl Med
Published: 2023/4/21
PubMed ID: 37082696