circRNA basic information
circBase ID: hsa_circ_0056881
Name: hsa_circ_DPP4
Synonym: circDPP4
Host Gene: hsa-miR-497-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PCa cell line (22RV1), normal cell line (RWPE-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GLUD1
Associated microRNA: hsa-miR-497-5p
Biological function: CircDPP4 silencing hindered the growth, motility and invasiveness of PCa cells. Conversely, silencing circDPP4 enhanced PCa cell apoptosis
Molecular mechanism: circDPP4/hsa-miR-497-5p/GLUD1 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

CircDPP4 facilitated PCa process by mediating the miR-497-5p/GLUD1 axis, providing a possible therapy target for PCa.
Other information
Title:

Circular RNA Dipeptidyl Peptidase 4 (circDPP4) Stimulates the Expression of Glutamate Dehydrogenase 1 to Contribute to the Malignant Phenotypes of Prostate Cancer by Sponging miR-497-5p.

Journal: Mol Biotechnol
Published: 2023/4/20
PubMed ID: 37079266