circRNA basic information
circBase ID: hsa_circ_0065214
Name: hsa_circ_SCAP
Synonym: circSCAP
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human bronchial epithelial cell line (16HBE), four NSCLC cell lines (SPCA1, A549, CALU3, H1229)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SMAD2
Associated microRNA: hsa-miR-7
Biological function: CircSCAP knockdown undermined cell proliferation, migration, and invasion abilities in NSCLC cell lines
Molecular mechanism: circSCAP/hsa-miR-7/SMAD2 axis, miRNA sponge
Survival: poor
Supported No.:
 2
Description:

In conclusion, this study demonstrates that circSCAP is significantly upregulated in NSCLC cell lines and tissues and elucidates that circSCAP facilitates NSCLC progression by sponging miR-7 and upregulating SMAD2.
Other information
Title:

EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling.

Journal: Environ Sci Pollut Res Int
Published: 2023/4/20
PubMed ID: 37079240