circRNA basic information
circBase ID: -
Name: hsa_circ_TNIK
Synonym: circTNIK
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZEB2
Associated microRNA: -
Biological function: Ectopic circTNIK expression promoted cell proliferation, invasion, tumorigenesis, and metastasis in gastric cancer cells whereas knockdown of circTNIK inhibited cell proliferation, invasion, tumorigenesis, and metastasis in gastric cancer cells
Molecular mechanism: circTNIK/hsa-miR-138-5p/ZEB2 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Overall, our study demonstrates how circTNIK regulates gastric cancer progression and metastasis by sponging miR-138-5p to modulate the expression of ZEB2.
Other information
Title:

Circular RNA circTNIK promotes tumor progression and metastasis in gastric cancer by regulating ZEB2.

Journal: J Gastroenterol Hepatol
Published: 2023/4/20
PubMed ID: 37078141