circRNA basic information
circBase ID: hsa_circ_0067301
Name: hsa_circ_PLXND1
Synonym: circ_PLXND1
Host Gene: hsa-miR-1287-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal bronchial epithelial cell line (16HBE), NSCLC cell line (H1299), NSCLC cell line (PC9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ERBB3
Associated microRNA: hsa-miR-1287-5p
Biological function: Circ_PLXND1 silencing suppressed the proliferation, angiogenesis, migration and invasion of NSCLC cells in vitro
Molecular mechanism: circ_PLXND1/hsa-miR-1287-5p/ERBB3 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_PLXND1 knockdown impeded NSCLC progression through modulating the miR-1287-5p/ERBB3 axis, indicating a promising molecular target for NSCLC treatment.
Other information
Title:

Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis.

Journal: Thorac Cancer
Published: 2023/4/19
PubMed ID: 37073425