circRNA basic information
circBase ID: hsa_circ_0003441
Name: hsa_circ_TDRD3
Synonym: circTDRD3
Host Gene: hsa-miR-891b
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Gastric cancer cell lines (HGC27, MGC803, MKN45, MKN28, SGC7901, AGS), human normal gastric mucosal epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ITGA2
Associated microRNA: hsa-miR-891b
Biological function: CircTDRD3 promoted GC cell proliferation and migration in vitro and in vivo
Molecular mechanism: circTDRD3/hsa-miR-891b/ITGA2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

ATF4-mediated circTDRD3 overexpression modulates the proliferation and metastasis of GC cells through the miR-891b/ITGA2 axis in a positive feedback manner.
Other information
Title:

ATF4-mediated circTDRD3 promotes gastric cancer cell proliferation and metastasis by regulating the miR-891b/ITGA2 axis and AKT signaling pathway.

Journal: Gastric Cancer
Published: 2023/4/17
PubMed ID: 37062785