circRNA basic information
circBase ID: hsa_circ_0058163
Name: hsa_circ_XRCC5
Synonym: circXRCC5
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CLC3, IGF2BP2, SGK1
Associated microRNA: -
Biological function: circXRCC5 knockdown inhibited cell proliferation and NLRP3-mediated inflammasome activation of glioma cells
Molecular mechanism: PI3K/PDK1/AKT pathway, circXRCC5/CLC3/SGK1 axis
Survival: poor
Supported No.:
 2
Description:

Our data concluded that circXRCC5 formed a complex with IGF2BP2 to regulate inflammasome activation and tumor growth via CLC3/SGK1 axis.
Other information
Title:

Circular RNA XRCC5 aggravates glioma progression by activating CLC3/SGK1 axis via recruiting IGF2BP2.

Journal: Neurochem Int
Published: 2023/4/16
PubMed ID: 37061192