circRNA basic information
circBase ID: hsa_circ_0081069
Name: hsa_circ_COL1A2
Synonym: circCOL1A2
Host Gene: hsa-miR-665
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LASP1
Associated microRNA: hsa-miR-665
Biological function: The proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) properties were inhibited after the reduction of exosomal circCOL1A2
Molecular mechanism: circCOL1A2/hsa-miR-665/LASP1 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

In conclusion, exosomal circCOL1A2 sponges miR-665 to enhance LASP1 expression and modulated CRC phenotypes. Thus, circCOL1A2 might be a valuable therapeutic target for CRC, offering novel insight into CRC treatment.
Other information
Title:

Exosomal circCOL1A2 from cancer cells accelerates colorectal cancer progression via regulating miR-665/LASP1 signal axis.

Journal: Eur J Pharmacol
Published: 2023/4/15
PubMed ID: 37059374