circRNA basic information
circBase ID: hsa_circ_0001771
Name: hsa_circ_RBM33
Synonym: circRBM33
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human prostatic epithelial cell line (RWPE-1), human prostate cancer cell lines (LNCaP, C4-2, PC-3, DU145, 22Rv1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FMR1, PDHA1, ARSI
Associated microRNA: -
Biological function: downregulation/upregulation of circRBM33 inhibited/promoted tumour growth and invasion, respectively
Molecular mechanism: circRBM33/FMR1/PDHA1 axis
Survival: -
Supported No.:
 1
Description:

Our study suggested that the m6A-mediated circRBM33-FMR1 complex can activate mitochondrial metabolism by stabilizing PDHA1 mRNA, which promotes PCa progression, and can attenuate circRBM33 increased ARSI effectiveness in PCa treatment.
Other information
Title:

M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy.

Journal: Int J Biol Sci
Published: 2023/4/15
PubMed ID: 37056926