circRNA basic information
circBase ID: hsa_circ_0076092
Name: hsa_circ_SCUBE3
Synonym: circSCUBE3
Host Gene: hsa-miR-744-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human gastric epithelial cell line (GES-1), human GC cell lines (HGC-27, MKN-45, NCI-N87)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SLC7A5, CD274
Associated microRNA: hsa-miR-744-5p
Biological function: circSCUBE3 knockdown could suppress GC immune escape
Molecular mechanism: -
Survival: poor
Supported No.:
 1
Description:

Our study revealed the importance of the circSCUBE3/miR-744-5p/SLC7A5 axis in GC immune escape and anti-PD-1 resistance.
Other information
Title:

CircSCUBE3 Reduces the Anti-gastric Cancer Activity of Anti-PD-L1.

Journal: Mol Biotechnol
Published: 2023/4/14
PubMed ID: 37052807