circRNA basic information
circBase ID: hsa_circ_0000677
Name: hsa_circ_ABCC1
Synonym: hsa_circABCC1
Host Gene: hsa-miR-591
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal osteoblasts (hFOB 1.19), osteosarcoma cell lines (U2OS, HOS, SAOS-2, SJSA-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HDAC4
Associated microRNA: hsa-miR-591
Biological function: Silencing of circABCC1 significantly reduced the viability and proliferation, promoted apoptosis, impaired migration and invasion, and increased autophagy of U2OS and HOS cells
Molecular mechanism: circABCC1/hsa-miR-591/HDAC4 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Silencing of circABCC1 inhibits osteosarcoma progression by attenuating HDAC4 expression through sponging miR-591.
Other information
Title:

Silencing circular RNA hsa_circABCC1 inhibits osteosarcoma progression through down-regulating HDAC4 via sponging miR-591.

Journal: Environ Toxicol
Published: 2023/4/14
PubMed ID: 37052456