circRNA basic information
circBase ID: hsa_circ_0008234
Name: hsa_circ_FOXP1
Synonym: -
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 219
DO name: colon cancer
Disease details: colon cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal colon epithelial cell (NCM460), colon cancer cell lines (HCT116, SW480, HCT8, DLD-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ETS1
Associated microRNA: hsa-miR-338-3p
Biological function: inhibiting hsa_circ_0008234 significantly reduced tumor growth and metastasis
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

In conclusion, hsa_circ_0008234 increases colon cancer proliferation, infiltration, and migration via the miR-338-3p/ETS1/PI3K/AKT axis; therefore, it could serve as a target and a focus for colon cancer therapy.
Other information
Title:

CircRNA RNA hsa_circ_0008234 Promotes Colon Cancer Progression by Regulating the miR-338-3p/ETS1 Axis and PI3K/AKT/mTOR Signaling.

Journal: Cancers (Basel)
Published: 2023/4/14
PubMed ID: 37046729