circRNA basic information
circBase ID: hsa_circ_0073453
Name: hsa_circ_RHOBTB3
Synonym: circ_0073453
Host Gene: hsa-miR-146a-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GC cell line (AGS, HGC-27, HEK-293T)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: IL-8
Associated microRNA: hsa-miR-146a-5p
Biological function: circ_0073453 was identified as a novel GC-MSC-derived circRNA which acted as a sponge of miR-146a-5p, thus increasing IL-8 expression and secretion to promote gastric cancer cell metastasis
Molecular mechanism: circ_0073453/hsa-miR-146a-5p/IL-8 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Taken together, our findings suggest that circ_0073453/miR-146a-5p/IL-8 axis is critical for GC-MSCs promoting gastric cancer progression. Hence, hsa_circ_0073453 may be a potential therapeutic target for gastric cancer.
Other information
Title:

Hsa_circ_0073453 modulates IL-8 secretion by GC-MSCs to promote gastric cancer progression by sponging miR-146a-5p.

Journal: Int Immunopharmacol
Published: 2023/4/13
PubMed ID: 37044033