circRNA basic information
circBase ID: hsa_circ_0006117
Name: hsa_circ_PTPRA
Synonym: circPTPRA
Host Gene: hsa-miR-140-5p
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal pancreatic ductal epithelial cell line (HPDE6-C7) , human PDAC cell lines (AsPC-1, BxPC-3, CFPAC-1, PANC-1, SW1990)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: LMNB1
Associated microRNA: hsa-miR-140-5p
Biological function: circPTPRA overexpression was positively correlated with lymph node invasion and worse prognosis in PDAC patients. In addition, overexpression of circPTPRA promoted PDAC migration, invasion, proliferation, and epithelial-mesenchymal transition (EMT) in vitro and in vivo
Molecular mechanism: circPTPRA/hsa-miR-140-5p/LMNB1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

This study revealed that circPTPRA plays an important role in the progression of PDAC by sponging miR-140-5p.
Other information
Title:

CircPTPRA promotes the progression of pancreatic ductal adenocarcinoma via the miR-140-5p/LMNB1 axis.

Journal: Cancer Med
Published: 2023/4/13
PubMed ID: 37041721