circRNA basic information
circBase ID: hsa_circ_0001079
Name: hsa_circ_STK39
Synonym: circ-STK39
Host Gene: hsa-miR-140-3p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: PC cell lines (PANC-1, AsPC-1, SW1990, Capan-2, BxPC3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRAM2
Associated microRNA: hsa-miR-140-3p
Biological function: Downregulation of circ-STK39 inhibited PC proliferation and migration
Molecular mechanism: circ-STK39/hsa-miR-140-3p/TRAM2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In this regard, we showed that circ-STK39 downregulation led to decreased migration, proliferation and the EMT of PC via the miR-140-3p/TRAM2 axis.
Other information
Title:

Downregulation of circ-STK39 suppresses pancreatic cancer progression by sponging mir-140-3p and regulating TRAM2-mediated epithelial-mesenchymal transition.

Journal: Apoptosis
Published: 2023/4/12
PubMed ID: 37041422