circRNA basic information
circBase ID: hsa_circ_0007142
Name: hsa_circ_DOCK1
Synonym: circDOCK1
Host Gene: hsa-miR-128-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Breast cancer cell lines (MCF-7, MDA-MB-231), human breast epithelial cell line (MCF10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NEK2
Associated microRNA: hsa-miR-128-3p
Biological function: circDOCK1 inhibition hindered breast cancer development by repressing NEK2 and thus promoting the increased expression of miR-128-3p both in vitro and in vivo.
Molecular mechanism: circDOCK1/hsa-miR-128-3p/NEK2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

We therefore conclude that circDOCK1 promotes breast cancer progression by targeting miR-128-3p-mediated downregulation of NEK2 and that the circDOCK1/hsa-miR-128-3p/NEK2 axis may be a novel therapeutic target for breast cancer treatment.
Other information
Title:

Circular forms of dedicator of cytokinesis 1 promotes breast cancer progression by derepressing never in mitosis related kinase 2 via sponging miR-128-3p.

Journal: Environ Toxicol
Published: 2023/4/12
PubMed ID: 37040338