circRNA basic information
circBase ID: hsa_circ_0008199
Name: hsa_circ_ATXN10
Synonym: circ8199
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: KYSE30, KYSE70, KYSE140, KYSE150, KYSE180, KYSE270, KYSE410, KYSE450, KYSE510, KYSE520, HET-1A cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: OGT, JAK2
Associated microRNA: -
Biological function: overexpression of circ8199 significantly inhibited the proliferation of ESCC cells and the activity of O-linked N-acetylglucosamine transferase (OGT) simultaneously
Molecular mechanism: JAK2-STAT3 pathway
Survival: -
Supported No.:
 1
Description:

Our study indicated that circ8199 regulates the JAK2-STAT3 pathway through OGT, providing a candidate mechanism for drug discovery and development.
Other information
Title:

Circ8199 encodes a protein that inhibits the activity of OGT by JAK2-STAT3 pathway in esophageal squamous cell carcinoma.

Journal: Am J Cancer Res
Published: 2023/4/11
PubMed ID: 37034230