circRNA basic information
circBase ID: -
Name: hsa_circ_ROBO1
Synonym: circROBO1
Host Gene: hsa-miR-130a-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (HepG2, SMMC-7721, Huh-7), normal hepatic cell line (LO2)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: CCNT2
Associated microRNA: hsa-miR-130a-5p
Biological function: knocking down circROBO1 significantly suppressed HCC cells growth in vitro and in mice
Molecular mechanism: circROBO1/hsa-miR-130a-5p/CCNT2 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Our findings firstly demonstrate that circROBO1 overexpression promotes HCC progression by regulating miR-130a-5p/CCNT2 axis, which may serve as an effective nanotherapeutic target for HCC treatment.
Other information
Title:

Nanoparticles Mediated circROBO1 Silencing to Inhibit Hepatocellular Carcinoma Progression by Modulating miR-130a-5p/CCNT2 Axis.

Journal: Int J Nanomedicine
Published: 2023/4/7
PubMed ID: 37020690