circRNA basic information
circBase ID: hsa_circ_0003928
Name: hsa_circ_TAOK1
Synonym: circ_0003928
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human tubular epithelial cell line (HK-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PAQR3
Associated microRNA: hsa-miR-136-5p
Biological function: Circ_0003928 knockdown promoted cell proliferation, and inhibit cell apoptosis, oxidative stress, and fibrosis in HK-2 cells under HG condition.
Molecular mechanism: circ_0003928/hsa-miR-136-5p/PAQR3 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

Circ_0003928 acted as a sponge of miR-136-5p to up-regulating PAQR3 expression, and then regulate the proliferation, oxidative stress, fibrosis and apoptosis in HG-induced HK-2 cells.
Other information
Title:

Hsa_circ_0003928 regulates the progression of diabetic nephropathy through miR-136-5p/PAQR3 axis.

Journal: J Endocrinol Invest
Published: 2023/4/6
PubMed ID: 37017919