circRNA basic information
circBase ID: hsa_circ_0001707
Name: hsa_circ_ABCA13
Synonym: circABCA13
Host Gene: hsa-miR-4429
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SRXN1
Associated microRNA: hsa-miR-4429
Biological function: While knockdown of circABCA13 in ESCC cells significantly reduced cell proliferation, migration, invasion, and anchorage-independent growth, overexpression of circABCA13 facilitated tumor growth both in vitro and in vivo.
Molecular mechanism: circABCA13/hsa-miR-4429/SRXN1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Collectively, our study uncovered the oncogenic role of circABCA13 and its mechanism in ESCC, suggesting that circABCA13 could be a potential therapeutic target and a predictive biomarker for ESCC patients.
Other information
Title:

CircABCA13 acts as a miR-4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1.

Journal: Cancer Sci
Published: 2023/4/6
PubMed ID: 37017121