circRNA basic information
circBase ID: hsa_circ_0000277
Name: hsa_circ_TNRC6B
Synonym: circ-TNRC6B
Host Gene: hsa-miR-452-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cell lines (TE-1, KYSE-30, KYSE-150, KYSE-170)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: DAG1
Associated microRNA: hsa-miR-452-5p
Biological function: Overexpression and knockdown functional experiments demonstrated that circ-TNRC6B inhibited ESCC cell proliferation, migration, and invasion
Molecular mechanism: circ-TNRC6B/hsa-miR-452-5p/DAG1 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

These findings demonstrated that circ-TNRC6B exerts a tumor-suppressing effect in ESCC through the miR-452-5p/DAG1 axis.
Other information
Title:

Circular RNA circ-TNRC6B inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by regulating the miR-452-5p/DAG1 axis.

Journal: Mol Oncol
Published: 2023/4/5
PubMed ID: 37014625