circRNA basic information
circBase ID: hsa_circ_0002612
Name: hsa_circ_SAMD4A
Synonym: circ_0002612
Host Gene: hsa-miR-30a-5p
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: myocardial ischemia-reperfusion injury
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: Ppargc1a, NLRP3
Associated microRNA: hsa-miR-30a-5p
Biological function: circ_0002612 promoted cardiomyocyte viability while suppressing the apoptosis by impairing the miR-30a-5p-mediated inhibition of Ppargc1a
Molecular mechanism: circ_0002612/hsa-miR-30a-5p/Ppargc1a/NLRP3 axis
Survival: -
Supported No.:
 1
Description:

Overall, this study demonstrates the cardioprotective role of circ_0002612 against MI/RI, which may be a viable target for MI/RI.
Other information
Title:

Cardioprotective effects of circ_0002612 in myocardial ischemia/reperfusion injury correlate with disruption of miR-30a-5p-dependent Ppargc1a inhibition.

Journal: Int Immunopharmacol
Published: 2023/4/5
PubMed ID: 37012879