circRNA basic information
circBase ID: hsa_circ_0046701
Name: hsa_circ_YES1
Synonym: circ-YES1
Host Gene: hsa-miR-142-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human pulmonary epithelial cells (BEAS-2B), NSCLC cells (H1650, A549, PC-9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-142-3p
Biological function: cell proliferation and migration were suppressed after circ-YES1 knockdown
Molecular mechanism: circ-YES1/hsa-miR-142-3p/HMGB1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, our results show that circ-YES1 promotes tumor development through the miR-142-3p-HMGB1 axis and support the development of circ-YES1 probability as a new therapeutic NSCLC target.
Other information
Title:

Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis.

Journal: Respir Res
Published: 2023/4/4
PubMed ID: 37009887