circRNA basic information
circBase ID: hsa_circ_0000512
Name: hsa_circ_RPPH1
Synonym: circRPPH1
Host Gene: hsa-miR-296-5p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human BCa cell lines (T24, 5637)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3
Associated microRNA: hsa-miR-296-5p
Biological function: CircRPPH1 downregulation could inhibit the proliferation, migration and invasion of BCa cells in vitro and in vivo
Molecular mechanism: circRPPH1/miR_296_5p/STAT3 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Overall, circRPPH1 could promote BCa progression through sponging miR_296_5p to upregulate the expression of STAT3 and interacting with FUS to promote p_STAT3 nuclear transport.
Other information
Title:

CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway.

Journal: Oncol Rep
Published: 2023/4/1
PubMed ID: 36999615