circRNA basic information
circBase ID: hsa_circ_0073228
Name: hsa_circ_RPS23
Synonym: circ_0073228
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cells (Huh-7, SNU-398), human liver cells (Clone 2.5 B1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DNASE2
Associated microRNA: hsa-miR-139-5p
Biological function: Inhibition of miR-139-5p or overexpression of DNASE2 counteracted the inhibitory effects of circ_0073228 knockdown on HCC cell progression
Molecular mechanism: circ_0073228/hsa-miR-139-5p/DNASE2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

circ_0073228 serves as an oncogene to facilitate growth and inhibit apoptosis of HCC cells by regulating the miR-139-5p/DNASE2 axis.
Other information
Title:

Circ_0073228 serves as a competitive endogenous ribonucleic acid to facilitate proliferation and inhibit apoptosis of hepatocellular carcinoma cells by the miR-139-5p/deoxyribonuclease II axis.

Journal: J Gene Med
Published: 2023/4/1
PubMed ID: 36999202