circRNA basic information
circBase ID: hsa_circ_0079440
Name: hsa_circ_PHF14
Synonym: circPHF14
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: gastric cancer cells (AGS, 7901)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DDX5
Associated microRNA: -
Biological function: silencing circPHF14 reverses the DDX5-induced tumor-promoting effects in gastric cancer cells
Molecular mechanism: circPHF14/DDX5 axis
Survival: -
Supported No.:
 2
Description:

These findings suggest that in addition to the messenger RNA and microRNA patterns, DDX5 also effects a circRNA pattern, as demonstrated by circPHF14. DDX5-induced circRNAs have been found to be of crucial importance for the growth of DDX5-positive gastric cancer cells, providing a new therapeutic target.
Other information
Title:

RNA helicase DDX5-induced circPHF14 promotes gastric cancer cell progression.

Journal: Aging (Albany NY)
Published: 2023/3/31
PubMed ID: 36996491