circRNA basic information
circBase ID: hsa_circ_0008529
Name: hsa_circ_ACTR2
Synonym: circACTR2, circRNA_102747
Host Gene: hsa-miR-221-3p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PC cell lines (PANC-1, SW1990, BxPC-3, CFPAC-1, AsPC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: hsa-miR-221-3p
Biological function: circACTR2 downregulation contributed to GEM chemoresistance of PC cells with decreased S phase ratio of cell cycle and cell apoptosis, as confirmed by gain- and loss-of-function assays in vitro. In addition, circACTR2 overexpression retarded GEM resistance in vivo
Molecular mechanism: circACTR2/hsa-miR-221-3p/PTEN, miRNA sponge, PI3K/AKT signaling pathway
Survival: better
Supported No.:
 1
Description:

circACTR2 reversed the chemoresistance of PC cells to GEM through inhibiting PI3K/AKT signaling pathway by sponging miR-221-3p and upregulating PTEN expression.
Other information
Title:

circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathway.

Journal: Biol Direct
Published: 2023/3/30
PubMed ID: 36991449