circRNA basic information
circBase ID: hsa_circ_0072088
Name: hsa_circ_ZFR
Synonym: circZFR
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: four PC cell lines (ASPC-1, BXPC-3, CAPAN-1, HS766T), human normal pancreatic ductal epithelial cell line (HPDE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GREM2
Associated microRNA: hsa-miR-375
Biological function: circZFR facilitated cell proliferation and enhanced tumorigenicity of PC
Molecular mechanism: circZFRhsa-miR-375/GREM2 axis, miRNA sponge, JNK pathway
Survival: poor
Supported No.:
 2
Description:

Collectively, our findings implicate circZFR as a positive regulator of PC progression through the miR-375/GREM2/JNK axis.
Other information
Title:

CircZFR promotes pancreatic cancer progression through a novel circRNA-miRNA-mRNA pathway and stabilizing epithelial-mesenchymal transition protein.

Journal: Cell Signal
Published: 2023/3/30
PubMed ID: 36990335