circRNA basic information
circBase ID: hsa_circ_0001017
Name: hsa_circ_XPO1
Synonym: circXPO1
Host Gene: hsa-miR-7-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human astrocyte cell line (NHA), human glioma cell lines (U87-MG, U251)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RAF1
Associated microRNA: hsa-miR-7-5p
Biological function: the knockdown of circXPO1 in GBM cell lines repressed cell proliferation and migration; conversely, the overexpression of circXPO1 promoted the malignancy of GBM cells. In line with these findings, circXPO1 inhibition effectively suppressed gliomagenesis in the in situ transplantation model of nude mice
Molecular mechanism: circXPO1/hsa-miR-7-5p/RAF1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In conclusion, our studies suggest that the circXPO1/miR-7-5p/RAF1 axis promotes brain tumor formation and may be a potential therapeutic target for GBM treatment.
Other information
Title:

CircXPO1 Promotes Glioblastoma Malignancy by Sponging miR-7-5p.

Journal: Cells
Published: 2023/3/30
PubMed ID: 36980172