circRNA basic information
circBase ID: hsa_circ_0052582
Name: hsa_circ_RRM2
Synonym: circRRM2
Host Gene: hsa-miR-31-5p, hsa-miR-27b-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human mammary epithelial cells (MCF-10A), BC cell lines (BT-474, BT-549, MCF-7, MDA-MB-231, MDA-MB-453, T47D)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF2BP1, MYC
Associated microRNA: hsa-miR-31-5p, hsa-miR-27b-3p
Biological function: High circRRM2 was significantly associated with advanced N stage in patients with BC. Gain- and loss- of function experiments revealed that circRRM2 promoted the migration and invasion of cells and functioned as an oncogene in BC
Molecular mechanism: circRRM2/hsa-miR-31-5p/hsa-miR-27b-3p/IGF2BP1/MYC axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

The positive feedback loop of circRRM2/IGF2BP1/MYC enforces the circRRM2 expression, which might offer a potential target for BC treatment.
Other information
Title:

A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis.

Journal: Cancer Cell Int
Published: 2023/3/26
PubMed ID: 36966311