circRNA basic information
circBase ID: hsa_circ_0001460
Name: hsa_circ_NEIL3
Synonym: circNEIL3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human breast cancer cell lines (BT549, MDA-MB-231), human lung cancer cell lines (A549, H1299), human colorectal cancer cell lines (SW480, SW620)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: YBX1
Associated microRNA: -
Biological function: circNEIL3 effectively inhibited tumor metastasis in both and in vivo and in vivo models of various cancer types
Molecular mechanism: circNEIL3/YBX1 axis
Survival: -
Supported No.:
 1
Description:

Collectively, our findings indicate the YBX1-dependent antimetastatic function of circNEIL3 and highlight the potential of circNEIL3 as a biomarker and therapeutic option in cancer treatment.
Other information
Title:

circNEIL3 inhibits tumor metastasis through recruiting the E3 ubiquitin ligase Nedd4L to degrade YBX1.

Journal: Proc Natl Acad Sci U S A
Published: 2023/3/25
PubMed ID: 36961927