circRNA basic information
circBase ID: hsa_circ_0001917
Name: hsa_circ_CASK
Synonym: circCASK
Host Gene: hsa-miR-1271-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human colorectal cell lines (SW620, SW480, HT29, HCT-8, HCT-15, HCT-116), a normal colonic epithelial cell line (FHC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SIX1
Associated microRNA: hsa-miR-1271-5p
Biological function: circCASK knockdown led to a significant decrease in CRC cell growth and attenuated cell migration and invasion. Similarly, circCASK knockdown markedly attenuated tumor growth in vivo
Molecular mechanism: circCASK/hsa-miR-1271-5p/SIX1 axis, miRNA sponge, Wnt/beta-catenin signaling pathways
Survival: -
Supported No.:
 1
Description:

In conclusion, circCASK induced by FOXC2 accelerated CRC progression through the miR-1271-5p/SIX1 axis, thus providing an interesting insight into CRC tumorigenesis.
Other information
Title:

FOXC2-induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression.

Journal: IUBMB Life
Published: 2023/3/25
PubMed ID: 36961205