circRNA basic information
circBase ID: hsa_circ_0000247
Name: hsa_circ_HMCU
Synonym: circHMCU
Host Gene: hsa-miR-4458
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: BC cell lines (MDA-MB-231, MCF-7), human embryonic kidney cell line (293 T), human normal mammary epithelial cell line (MCF10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PGK1
Associated microRNA: hsa-miR-4458
Biological function: circHMCU knockdown inhibited cell proliferation, migration, glycolysis, while promoted cell apoptosis
Molecular mechanism: circHMCU/hsa-miR-4458/PGK1 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

CircHMCU acted as an oncogenic factor by regulating the miR-4458/PGK1 axis in BC.
Other information
Title:

Circular RNA circHMCU promotes breast tumorigenesis through miR-4458/PGK1 regulatory cascade.

Journal: Hereditas
Published: 2023/3/24
PubMed ID: 36949536