circRNA basic information
circBase ID: hsa_circ_0003528
Name: hsa_circ_SEC24A
Synonym: circ_0003528
Host Gene: hsa-miR-511-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Calu-6, A549
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDL1
Associated microRNA: hsa-miR-511-3p
Biological function: Silence of circ_0003528 decreased xenograft growth in mouse models and induced cell apoptosis and repressed cell viability, proliferation, invasion, EMT, angiogenesis, and immune escape in NSCLC cells in vitro
Molecular mechanism: circ_0003528/hsa-miR-511-3p/PDL1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Circ_0003528 facilitated NSCLC cell malignant transformation and immune escape through regulation of the miR-511-3p/PDL1 axis, highlighting the oncogenic role of circ_0003528 in NSCLC.
Other information
Title:

Hsa_circ_0003528 promotes cell malignant transformation and immune escape via increasing oncogene PDL1 through sponging miR-511-3p in non-small cell lung cancer.

Journal: Environ Toxicol
Published: 2023/3/23
PubMed ID: 36947452