Our study elucidates a link between SiO2-induced macrophage activationand the circZC3H4 RNA/ZC3H4 pathway, thereby providing novel insight into the potentialuse of ZC3H4 to develop novel therapeutic strategies for silicosis.
Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation.