circRNA basic information
circBase ID: hsa_circ_0058063
Name: hsa_circ_ATIC
Synonym: circ_0058063
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OSCC (HSC-2, HSC-4, SCC-25, SCC-9), human immortalized oral epithelial (HIOEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PI3K, AKT
Associated microRNA: hsa-miR-145-5p
Biological function: Upregulation of circ_0058063 levels enhanced the viability, adhesion, migration, and EMT of OSCC cells in vitro and promoted tumorigenicity in vivo
Molecular mechanism: PI3K/AKT pathway, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our results revealed that circ_0058063 functions as an oncogene via regulation of the PI3K/AKT pathway by targeting miR-145-5p in OSCC, suggesting its potential for OSCC diagnosis and treatment.
Other information
Title:

Circ_0058063 Contributed to Oral Squamous Cell Carcinoma Development by Sponging miR-145 and Regulating PI3K/AKT Pathway.

Journal: Mol Biotechnol
Published: 2023/3/18
PubMed ID: 36928742